ABSTRACT
Dental Caries is a kind of chronic oral disease that greatly threaten human being's health. Though dentists and researchers struggled for decades to combat this oral disease, the incidence and prevalence of dental caries remain quite high. Therefore, improving the disease management is a key issue for the whole population and life cycle management of dental caries. So clinical difficulty assessment system of caries prevention and management is established based on dental caries diagnosis and classification. Dentists should perform oral examination and establish dental records at each visit. When treatment plan is made on the base of caries risk assessment and carious lesion activity, we need to work out patient‑centered and personalized treatment planning to regain oral microecological balance, to control caries progression and to restore the structure and function of the carious teeth. And the follow-up visits are made based on personalized caries management. This expert consensus mainly discusses caries risk assessment, caries treatment difficulty assessment and dental caries treatment plan, which are the most important parts of caries management in the whole life cycle.
Subject(s)
Humans , Consensus , Dental Care , Dental Caries/prevention & control , PrevalenceABSTRACT
For adapting to the change of modern medical model and suiting social demand of high quality dentists, this paper compares the differences of undergraduate education in stomatology between China and Russia by using the method of Bereday comparative education, trying to provide some reference for the reform of Chinese stomatology education. Curriculum arrangement in China is being constantly explored based on the Russian model. In China, courses are divided into basic medicine, clinical medicine and stomatology in three stages, making students relatively passive in learning. And the ratio of practice to lecture is far more higher in Russia than that in China. Thus, it's necessary to optimize structure and balance the distribution of stomatological curriculum in China, improve and popularize learning models such as problem -based learning (PBL) and so on, so as to promote the development of stomatology education of China to a higher level.
ABSTRACT
Medication-related osteonecrosis of the jaw (MRONJ) is a serious side effect of bone-modifying agents and inhibits angiogenesis agents. Although the pathogenesis of MRONJ is not entirely clear, multiple factors may be involved in specific microenvironments. The TGF-β1 signalling pathway may have a key role in the development of MRONJ. According to the clinical stage, multiple variables should be considered when selecting the most appropriate treatment. Therefore, the prevention and management of treatment of MRONJ should be conducted in patient-centred multidisciplinary team collaborative networks with oncologists, dentists and dental specialists. This would comprise a closed responsibility treatment loop with all benefits directed to the patient. Thus, in the present review, we aimed to summarise the pathogenesis, risk factors, imaging features, clinical staging, therapeutic methods, prevention and treatment strategies associated with MRONJ, which may provide a reference that can inform preventive strategies and improve the quality of life for patients in the future.
Subject(s)
Humans , Bisphosphonate-Associated Osteonecrosis of the Jaw/prevention & control , Bone Density Conservation Agents/adverse effects , Quality of Life , Risk FactorsABSTRACT
Collectively migrating tumor cells have been recently implicated in enhanced metastasis of epithelial malignancies. In oral squamous cell carcinoma (OSCC), v integrin is a crucial mediator of multicellular clustering and collective movement ; however, its contribution to metastatic spread remains to be addressed. According to the emerging therapeutic concept, dissociation of tumor clusters into single cells could significantly suppress metastasis-seeding ability of carcinomas. This study aimed to investigate the anti-OSCC potential of novel endostatin-derived polypeptide PEP06 as a cluster-dissociating therapeutic agent . Firstly, we found marked enrichment of v integrin in collectively invading multicellular clusters in human OSCCs. Our study revealed that metastatic progression of OSCC was associated with augmented immunostaining of v integrin in cancerous lesions. Following PEP06 treatment, cell clustering on fibronectin, migration, multicellular aggregation, anchorage-independent survival and colony formation of OSCC were significantly inhibited. Moreover, PEP06 suppressed v integrin/FAK/Src signaling in OSCC cells. PEP06-induced loss of active Src and E-cadherin from cell-cell contacts contributed to diminished collective migration of OSCC . Overall, these results suggest that PEP06 polypeptide 30 inhibiting v integrin/FAK/Src signaling and disrupting E-cadherin-based intercellular junctions possesses anti-metastatic potential in OSCC by acting as a cluster-dissociating therapeutic agent.
ABSTRACT
Objective: To investigate the effect of self-etching adhesive with different unsealing time on the microleakage of the adhesive interface between tooth and resin. Methods: Unopened self-etching adhesives, Scotchbond Universal (S) and Xeno V+ (X) were respectively used to adhere Z350 resin for restoration of the prepared occlusal cavities sized 4 mm × 4 mm × 4 mm (n = 40) . The methylene blue staining method was used to observe the microleakage of the adhesive interface between the tooth and filling material at the instant moment, 1, 2 and 3 months after the self-etching adhesives was opened (n = 10) . Results: (1) Increase of microleakage in S group was found with the time span after unsealing, and there was a statistical difference between the instant moment and 3 months after unsealing (P＜0. 05) . (2) There was no significant difference at the 4 test time points in X group (P＞0. 05), although the microleakage value of the samples were increased with the increase of the time after unsealing. (3) The microleakage of X group was greater than that of S group at the instant moment and 1 month after unsealing (P＜0. 05) . Conclusion: Unsealing time may increase the microleakage of the adhesive interface between the tooth and the filling material, the effect varies with the types of the adhesives.
ABSTRACT
Objective:To explore the effects of surface bonding on compressive strength of chemically-cured(Dycal) and light-cured (Calcimol LC) calcium hydroxide.Methods:32 experimental specimens were prepared and divided into 4 groups(n =8):Group A,Dcyal without surface bonding;Group B,Calcimol LC without surface bonding;Group C,Dycal with surface bonding;Group D,Calcimol LC with surface bonding.German Zwick universal electronic testing machine was used to test the compressive strength of the specimens.Results:The average compressive strength value of group A,B,C and D was (110.48 ± 19.9),(162.6 ±7.8),(136.8 ± 17.2) and (223 ± 31.1) MPa respectively.Among them,the compressive strength of Group D was the highest (P ＜ 0.05).Compressive strength value of group B was higher than that of group A (P ＜ 0.05).No statistical difference was detected between other groups.Conclusion:The compressive strength of Light-cured Calcium Hydroxide is higher than that of chemically-cured Calcium Hydroxide.Surface bonding treatment can improve the compressive strength of Light-cured Calcium,no apparent effects can be produced on chemicallycured Calcium Hydroxide.